"Clinical Pathology" LAB

Principal Investigator: Prof. Massimiliano Marco Romanelli MD PhD Full Professor of Clinical Pathology and Director of Operative Unit Laboratory Medicine 1 - Clinical Pathology, Department of Human Services Diagnosis and Care, IRCCS Policlinico San Donato

Members: Dr. Emanuela Rita Galliera PhD, Assistant Professor of Clinical Pathology MED/05 (Department Biomedical Sciences, Surgical and Dental), Dr. Elena Dozio, postgraduate PhD, Dr. Elena Vianello, PhD, Dr. Monica Gioia Marazzi, graduate degree in technical sciences diagnostics; Lucia Salcito, student.

The group’s research activity is focused on: The laboratory has always been involved in pathophysiology and translational medicine: the study of new biomarkers in immunopathology, and in neurodegenerative diseases. Over the past 10 years due to both direct collaboration with the Orthopaedic Istitute R.Galeazzi IRCCS, and the IRCCS Policlinico San Donato, research involved the new fields of osteoimmunology and cardiovascular disease.

Currently, the research has its primary focus on two major research lines:

- Topic 1. Osteoimmunology is a new branch that deals with studying the relationship between the immune system and bone. In recent years have brought to light numerous data confirm this relationship(Dr. Galliera, Dr. Marazzi, Prof. Corsi Romanelli)

- Topic 2. The epicardial adipose tissue is not a bad fat, has a structural function, serves to maintain the seat in coronary and works as a deposit of lipids. If, however, it greatly increases it becomes a mirror of the general state of the organism and produces molecules (cytokines, chemokines, and adipokines) that operate locally on the heart or at systemic level in the obese. These molecules have a strong inflammatory activity, which can be reversible: if you lose weight, in fact, also the epicardial adipose tissue decreases. (Dr. Dozio, Dr Vianello, Prof. Corsi Romanelli)

foto Prof. Corsi

Recent/relevant Publications :

1: Dozio E, Dogliotti G, Malavazos AE, Bandera F, Cassetti G, Vianello E, Zelaschi R, Barassi A, Pellissero G, Solimene U, Morricone L, Sigruener A, Tarabin V, Schmitz G, Menicanti L, Corsi Romanelli MM. IL-18 level in patients undergoing coronary artery bypass grafting surgery or valve replacement: which link with epicardial fat depot? Int J Immunopathol Pharmacol. 2012;25(4):1011-20. IF 2.9

2: Dozio E, Barassi A, Dogliotti G, Malavazos AE, Colpi GM, D'Eril GV, Corsi MM. Adipokines, hormonal parameters, and cardiovascular risk factors: similarities and differences between patients with erectile dysfunction of arteriogenic and nonarteriogenic origin. J Sex Med. 2012;9(9):2370-7. IF 3.55

3: Iacobellis G, Malavazos AE, Corsi MM. Epicardial fat: from the biomolecular aspects to the clinical practice. Int J Biochem Cell Biol. 2011;43(12):1651-4. IF 4.63

4: Corsi MM, Licastro F, Porcellini E, Dogliotti G, Galliera E, Lamont JL, Innocenzi PJ, Fitzgerald SP. Reduced plasma levels of P-selectin and L-selectin in a pilot study from Alzheimer disease: relationship with neuro-degeneration. Biogerontology. 2011;12(5):451-4. IF 3.33

5: Magni P, Dozio E, Galliera E, Ruscica M, Corsi MM. Molecular aspects of adipokine-bone interactions. Curr Mol Med. 2010;10(6):522-32. IF 4.47

6: Galliera E, Banfi G, Corsi MM. Human bone disorders: pathological role and diagnostic potential of matrix metalloproteinases. Int J Biochem Cell Biol. 2010;42(10):1590-3. IF 4.63

International collaborations:

1) Prof. Gianluca Iacobellis, University of Miami, USA

2) Prof. Gerd Schmitz, Regensburg Universitat, Germany

3) Prof Michael Oellerich, Gottingen Universitat, Germany

Contacts:

Prof. M.M.Corsi Romanelli: Università tel/fax 02-50315341- Ospedale tel/fax 02-52774662, email mmcorsi@unimi.it

Dr.ssa E.R. Galliera: tel. 02-50315354 email emanuela.galliera@unimi.it

Dr.ssa E. Dozio tel. 02-50315342 email elena.dozio@unimi.it

Dr.ssa E. Vianello tel. 02-50315342 email elena.vianello@unimi.it

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